Phd Position: Biomolecular Condensates in Synthetic

2 maanden geleden

Nijmegen, Nederland Radboud Universiteit Voltijd

Employment
1.0 FTE
Gross monthly salary
€ 2,872 - € 3,670
Required background
Research University Degree
Organizational unit
Faculty of Science
Application deadline
05 January 2025
Synthetic cells hold great promise in the development of innovative therapeutic strategies. However, molecular payloads synthesised inside synthetic cells must be secreted and new molecular building blocks or drugs must be delivered to synthetic cells in a smart and programmable way. Condensates have recently been shown to interact with membranes in a rich and dynamic way, including the possibility of entering giant unilamellar vesicles (GUVs) via endocytosis. In this project, you will develop synthetic cells and condensates that exhibit a tunable affinity for the GUV inner membrane. The membrane affinity will be controlled via biochemical pathways that regulate ATP levels and that regulate the self-organisation of protein filaments. Enzyme-controlled condensates will be directed to the membrane, where condensate property modulation and membrane remodelling are used to directly uptake or secrete condensates through membrane wrapping to deliver biomolecular payloads concentrated inside the condensates. This may enable future use of synthetic cells for the development of RNA and protein-based therapeutics.
You will communicate your findings in papers in peer-reviewed journals and at international conferences. You will also be involved in training and teaching BSc and MSc students.
**Selected References**:
S. Javed, E. Spruijt, Spontaneous wrapping of coacervates by lipid bilayers upon heat shock creates resilient and intact membranized coacervates, ChemRxiv (2024); DOI 10.26434/chemrxiv-2024-f4gls
Profile
You have a Master’s degree in molecular life sciences, chemistry, chemical biology or a related discipline.
You have demonstrated knowledge of at least one of the following: biomolecular condensates, coacervates, membrane biophysics, enzymology, colloidal physical chemistry.
You have excellent communication skills and a good command of both written and spoken English.
**You meet the EU MSCA doctoral network mobility criteria**: you must not have resided or carried out your main activity (work, studies, etc.) in the country of the recruiting organisation for more than 12 months in the 36 months immediately before the recruitment date.
We are
The Spruijt Lab has extensive experience in designing and characterising model biomolecular condensates and studying their impact on enzymatic networks, protein aggregation and membrane deformation. The main objective of this project is to harness the power and versatility of enzymatic networks to achieve spatiotemporal, and genetically programmable control over biomolecular condensates inside synthetic cells. Enzymes involved in the ATP metabolism will be localised to peptide-based condensates and their activity will be used to modulate the condensate surface tension, charge and material properties. The aim is to develop a programmable approach for localisation and membrane adhesion of condensates in synthetic cells, ultimately leading to exocytosis and division of these synthetic cells. This project will advance our understanding of condensate dynamics and function, both in synthetic biology and in living cells.
Radboud University
At Radboud University, we aim to make an impact through our work. We achieve this by conducting groundbreaking research, providing high-quality education, offering excellent support, and fostering collaborations within and outside the university. In doing so, we contribute indispensably to a healthy, free world with equal opportunities for all. To accomplish this, we need even more colleagues who, based on their expertise, are willing to search for answers. We advocate for an inclusive community and welcome employees with diverse backgrounds, cultures, and perspectives. Will you also contribute to making the world a little better? You have a part to play.
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Faculty of Science
The Faculty of Science (FNWI), part of Radboud University, engages in groundbreaking research and excellent education. In doing so, we push the boundaries of scientific knowledge and pass that knowledge on to the next generation.
We seek solutions to major societal challenges, such as cybercrime and climate change and work on major scientific challenges, such as those in the quantum world. At the same time, we prepare our students for careers both within and outside the scientific field.
Currently, more than 1,300 colleagues contribute to research and education, some as researchers and lecturers, others as technical and administrative support officers. The faculty has a strong international character with staff from more than 70 countries. Together, we work in an informal, accessible and welcoming environment, with attention and space for personal and professiona

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