Phd Candidate

3 maanden geleden


Maastricht, Nederland Maastricht University Voltijd

Physiological and Accelerated Pacing in Patients with Heart Failure with Preserved Ejection Fraction and Patients with Atrial Fibrillation.

Background
Heart failure (HF) is a prevalent clinical syndrome with diverse phenotypes. HF with preserved ejection fraction (HFpEF) accounts for over 50% of HF diagnoses. Despite its increasing incidence, HFpEF lacks targeted treatments. Pacing to modify resting heart rate (HR) has shown promising therapeutic potential for this complex patient population.

This research project aims to:

- Investigate the hemodynamic effects and outcomes of elevated resting HR through accelerated atrioventricular physiological (conduction system) pacing in HFpEF patients without pacemaker indications, and to elucidate the mechanisms by which this intervention influences cardiac hemodynamics and pump function.
- Evaluate whether accelerated physiological pacing improves outcomes in patients with atrial fibrillation (AF) who undergo a pace and ablate strategy.

The project encompasses hemodynamic and follow-up studies in HFpEF and AF patients, as well as patient-specific (Digital Twin) simulations based on non-invasive echocardiographic and invasive pressure data integrated into the CircAdapt model of the human cardiovascular system.

During this 4-year PhD project, you will join a high-profile interdisciplinary research team (Departments of Cardiology and Biomedical Engineering) and collaborate closely with other scientists within the experimental and clinical divisions of our department.

Your responsibilities will include:

- Supporting hemodynamic measurements at the cardiac catheterization laboratories during pacemaker implantations.
- Investigating the immediate impact of an accelerated heart rate induced by AV-sequential pacing on Pulmonary Capillary Wedge Pressure (PCWP) in selected HFpEF patients and patients with AF.
- Evaluating the mid-term outcomes of this pacing intervention in these patients.
- Participating in (but not primarily responsible for) modeling experiments at the Department of Biomedical Engineering.

Your work will significantly contribute to the optimization of management strategies for patients with HFpEF and AF. Additionally, you will have the opportunity to enhance your clinical and research skills through a variety of courses, workshops, and seminars.

**Requirements**:

- A Master’s degree (or equivalent) in medicine.
- Enjoy working in an interdisciplinary research team and can communicate effectively across various disciplines.
- Demonstrate an independent and well-structured working style.
- Demonstrable affinity with scientific research and/or cardiology is considered a plus.

**What we offer**
- Good employment conditions. The position is graded in scale P according to UFO profile PhD, with corresponding salary based on experience ranging from €2872,00 and €3670,00 gross per month (based on a full-time employment of 38 hours per week). In addition to the monthly salary, an 8.0% holiday allowance and an 8.3% year-end bonus apply.
- An employment contract for a period of 12 months with a scope of 1,0 FTE. Upon a positive evaluation, an extension of 3 years will follow.
- At Maastricht University, the well-being of our employees is of utmost importance, we offer flexible working hours and the possibility to work partly from home if the nature of your position allows it. You will receive a monthly commuting and internet allowance for this. If you work full-time, you will be entitled to 29 vacation days and 4 additional public holidays per year, namely carnival Monday, carnival Tuesday, Good Friday, and Liberation Day. If you choose to accumulate compensation hours, an additional 12 days will be added. Furthermore, you can personalize your employment conditions through a collective labor agreement (CAO) choice model.
- As Maastricht University, we offer various other excellent secondary employment conditions. These include a good pension scheme with the ABP and the opportunity for UM employees to participate in company fitness and make use of the extensive sports facilities that we also offer to our students. Last but certainly not least, we provide the space and facilities for your personal and professional development. We facilitate this by offering a wide range of training programs and supporting various well-established initiatives such as 'acknowledge and appreciate'.The terms of employment at Maastricht University are largely set out in the collective labor agreement of Dutch Universities. In addition, local provisions specific to UM apply. For more information, click here.

**Maastricht University**
Why work at Maastricht University?
At Maastricht University (UM), everything revolves around the future. The future of our students, as we work to equip them with a solid, broad-based foundation for the rest of their lives. And the future of society, as we seek solutions through our research to issues from all around the world. Our six faculties c



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