Postdoc Immune-metabolic Profiling in Multiple Myeloma

6 dagen geleden


Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

**About the project**:
Multiple myeloma (MM) is characterized by a broad range of immune evasion strategies, that result in abnormalities in immune cell (and particularly T-cell) responses. Cumulative exposure to several anti-MM drugs reduce T-cell numbers or induce functional T-cell defects. In addition, increasing evidence suggests that the MM microenvironment, which consists of several components, including BM stromal cells (BMSCs), immune suppressor cells and immunosuppressive molecules, promotes tumor growth, impairs immune responses and limits the efficacy of anticancer treatments including T-cell redirecting bispecific antibodies.

So far, in depth understanding of the local and systemic immune dynamics during treatment with conventional flow cytometry has been restricted by the limited number of markers that can be detected simultaneously, imposing the need for large amount of input material. Most importantly, however, current immune profiling methods do not address the actual immune cell functional status.

Recently, it became clear that virtually all aspects of immune cell function, including differentiation, migration and secretion of immunomodulatory molecules, are regulated by dynamic changes in cellular metabolism. As an example, glycolysis has a crucial role in T cell effector function as well as in the immuno-stimulatory activity of antigen presenting cells, while fatty acid oxidation controls the development of regulatory T cells and tolerogenic dendritic cells. Importantly, recent groundbreaking studies revealed that the metabolic status can functionally discriminate T cell subsets sharing common phenotypic features that cannot be resolved using traditional markers. This underscores the potential of immune-metabolic profiling to uncover the immune dynamics that preclude effective antitumor immunity, and provide new insights into strategies to improve therapy response

**About the role**:
Using cutting-edge spectral flow cytometry and cellular and molecular biology techniques, the immune-metabolic profiling team you will be part of will:

- Determine how tumor cells influence the blood and bone marrow immune landscape and functional status in multiple myeloma;
- Explore the alterations of the blood and bone marrow immune environment induced by anti-MM therapies (with a focus on T-cell redirecting bispecific antibodies)
- Explore which factors predict durable response or MRD-negativity;
- Study the mechanisms underlying immune alterations with a particular focus on communication mediated by extracellular vesicles (EVs) using relevant in vitro 3D systems.

**Profile**:
You will be part of a dynamic, international research group and feel comfortable working in an interdisciplinary, cross-cultural environment. As an enthusiastic scientist, you should also meet the following qualifications:

- PhD in immunology, oncology or other related fields;
- Extensive experience with spectral flow cytometry and analysis;
- Familiarity with cell culture and molecular biology techniques (preferred);
- Proficiency in spoken and written English.

**Our offer**:

- A flying start to your career in scientific research.
- Plenty of room for your drive to shape tomorrow's healthcare.
- Working on large-scale and in-house research, with motivated colleagues from all over the world.
- You will be employed by Amsterdam UMC Research BV.
- Salary scale 10: € 3.493 to € 5.504 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here.
- Holiday hours: 186,4 per year for fulltime and a possibility to save additional hours.
- Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
- For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
- Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

**About the workplace**:
Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.

Watch the video to find out more.

**Let's meet**:
A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Acquisition in response to this vacancy is not appreciated.


  • Metabolic Institute

    1 dag geleden


    Amsterdam Noord, Nederland Metabolic Voltijd

    **About the Metabolic Institute** The Institute’s multidisciplinary team works across a range of topics, including: circular cities and regions, industrial ecology, sustainable value chains (e.g. built environment, têxtiles, agrifood, energy, plastics), environmental monitoring and evaluation, circular entrepreneurship, and impact finance. To gain a...

  • Research Technician

    4 weken geleden


    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the role**: Your primary responsibility, although not restricted to, will be to isolate cells from blood and bone marrow samples of patients with multiple myeloma to enable this research. You will also be involved in organizational task including database generation and maintenance. **Profile**: We seek a highly motivated research technician who...


  • Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    Postdoc in Conquering Therapy Resistance in Multiple Myeloma using Advanced Computational Tools **Faculty/Services**:Faculty of Science **Educational level**:PhD **Function type**:Postdoc **Closing date**:20.01.2025 **Vacancy number**:13714 - Join us! - MM is the second-most common hematological cancer, with a rising incidence in the increasingly aging...

  • Postdoc Neuro-immunology

    2 maanden geleden


    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the project**: This collaborative project is embedded in the Amsterdam Institute for Infection and Immunity and is funded by the ADORE Foundation. **ADORE**, which stands for **A**mster**D**am **O**ncology and Neuroscience **RE**search, is a collaborative effort between the Cancer Center Amsterdam and Amsterdam Neuroscience, comprising a total of...

  • Data Analyst Internship

    1 dag geleden


    Amsterdam Noord, Nederland Metabolic Voltijd

    **About Metabolic** Metabolic’s mission is to transition the global economy to a fundamentally sustainable state. We advise governments, businesses, and NGOs on how to adapt to a fast-changing global context. Combining systems thinking and data science, we map and understand local and global systems to assess where to intervene and develop solutions that...


  • Amsterdam Oost, Nederland AMOLF Voltijd

    **Postdoc: Single-molecule microscopy of checkpoint therapeutic action on T cells**: **Work Activities**: As postdoc member of the REPRESSIT consortium coordinated the Physics of Cellular Interactions group headed by Dr. Kristina Ganzinger, you will work on developing a new type of cancer therapeutic (checkpoint inhibitor) in a biophysical project right at...


  • Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the role**: Your primary responsibility, although not restricted to, will be to isolate and biobank cells from cancer patient blood and bone marrow, to enable research into the immune-metabolic landscape and T-cell immunotherapy response. **Profile**: - You're pursuing a medical/technical degree; - Fluency in spoken English and proficiency in...

  • Office Manager

    7 maanden geleden


    Amsterdam Noord, Nederland Metabolic Voltijd

    **About Metabolic** Metabolic’s mission is to transition the global economy to a fundamentally sustainable state. Based in the Netherlands, we are an international and dynamic team of around 100 people who share an ambition for catalyzing a sustainable future. Our primary language is English. **About the Position** Our Operations team plays an...

  • Circular Cities

    1 dag geleden


    Amsterdam Noord, Nederland Metabolic Voltijd

    **About Metabolic** Metabolic’s mission is to transition the global economy to a fundamentally sustainable state. We advise governments, businesses, and NGOs on how to adapt to a fast-changing global context. Combining systems thinking and data science, we map and understand local and global systems to assess where to intervene and develop solutions that...


  • Amsterdam-Zuidoost, Nederland Amsterdam UMC Voltijd

    **About the project**: **Lysosomes** are known as the recycling centers of the cell, breaking down and recycling cellular waste, macromolecules, and organelles to maintain cell health. As we age, lysosomal function can decline, leading to an accumulation of cellular debris and dysfunctional proteins, which is thought to contribute to the aging process and...


  • Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: VUSec performs world-leading research in the broad area of systems security. We work on attacks, defenses, reverse engineering, and formal verification of security. We cover all major areas where security is important, especially software security, hardware security, and network security. We love to work on low-level stuff, for example...

  • Postdoc Datamanager Biodora

    4 weken geleden


    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **Wat ga je onderzoeken**: Binnen Amsterdam UMC gaan patiëntenzorg en wetenschappelijk onderzoek hand in hand. Alle patiënten die in het kader van diagnostiek en behandeling onze poli bezoeken, worden gevraagd om deel te nemen aan wetenschappelijke onderzoeken om de diagnose en behandeling van kanker en neurodegeneratieve ziekten te verbeteren. Zowel voor...


  • Amsterdam, Nederland Koninklijke Nederlandse Akademie van Wetenschappen Voltijd

    **Location**:Amsterdam **Max hours per week**:38 **Max salary**:5090,00 **Duration of agreement**:1 - 3 years **Postdoc in social rodent neuroscience: understanding social and brain dynamics of multiple individuals** Both human and rodents live in complex environments that include the necessity to interact with other conspecifics. To better understand...


  • Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    Postdoc on Supporting Human Decision Making with Reinforcement Learning **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Gepromoveerd**Functie type**:Researcher**Sluitingsdatum**:29 november 2024**Vacaturenummer**:13547 - Do you like to investigate how reinforcement learning agents can optimally support human decision...


  • Amsterdam, Nederland Universiteit van Amsterdam Voltijd

    Postdoc Position on Optical Atomic Clocks **Faculty/Services**:Faculty of Science**Educational level**:PhD**Function type**:Postdoc**Closing date**:31 March 2025**Vacancy number**:13211- - Join the UvA!- **What are you going to do?** - You will work on two projects. You and the QDNL team will design and build a highly reliable optical lattice clock, based...

  • Research Technician Lsmb

    7 maanden geleden


    Amsterdam Zuid, Nederland Amsterdam UMC Voltijd

    **About the project**: Our group aims to attain broader relevance of CAR-T cell therapy through improvement of tumor targeting and tumor elimination, overcoming resistance, minimization of off-tumor toxicity and expansion of the availability across histocompatibility barriers. We use iPSCs as an unlimited source of off-the-shelf CAR-T cells and have...

  • Postdoc Preventive Dentistry

    6 maanden geleden


    Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: **Project description** Antibiotic resistance is a major and ever-increasing health threat, projecting to result in 10 million deaths annually by 2050. An often-overlooked cause for this resistance is the fact that many antibacterial agents are unable to effectively target intracellular bacteria. Hidden inside their host cells, these...


  • Amsterdam, Nederland Koninklijke Nederlandse Akademie van Wetenschappen Voltijd

    **Location**:Amsterdam **Max hours per week**:38 **Max salary**:5278,00 **Duration of agreement**:1 - 3 years **Postdoc in social rodent neuroscience: understanding social and brain dynamics of multiple individuals** Both human and rodents live in complex environments that include the necessity to interact with other conspecifics. To better understand how...


  • Amsterdam Zuid, Nederland Vrije Universiteit Amsterdam Voltijd

    **Your function**: In this exciting postdoc position, you will conduct applied research to address a major knowledge gap on how to scale Nature Based Solutions in an equitable and just way. Using political sciences and economics, you will independently develop research activities in our FairNature project, funded by Biodiversa+ under the call “Nature-Based...


  • Amsterdam Oost, Nederland AMOLF Voltijd

    **Work Activities**: **Summary -** In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into specific functional cell types, and hence reveal how functional...