Transmembrane Protein Mimics for Communication

4 dagen geleden

Amsterdam Oost, Nederland AMOLF Voltijd

**Work Activities**:
More about the project

Functionalizing synthetic cells with transmembrane proteins is still a technical bottleneck. You will circumvent the need to solve this technical challenge time and again by generating a modular toolbox for trans-membrane protein mimics - an approach centered around transmembrane peptides. The central goal is to have a protocol for firstly integrating a transmembrane peptide in lipid vesicles (phase-transfer, microfluidics), and then functionalizing it in a second step with an extracellular component for signal sensing and an intracellular component for signal propagation via bio-orthogonal chemistries. In short: you will work on bio-inspired communication across synthetic membranes without the need for laborious transmembrane protein purification/insertion or transport across the membranes. The modular “LEGO” approach means that it would open a general route for generating bespoke artificial receptors for bottom-up synthetic biology in the future. In order to answer these questions, you will integrate methods from synthetic biology and biochemistry to create functionalized lipid vesicles, and use (single-molecule) fluorescence microscopy to study their properties.

More about the SigSynCell MSCA Doctoral Training Network

**Qualifications**:
You are an experimental (bio)chemist or molecular biologist with a strong interest in synthetic biology and/or biophysical questions. Experience with either protein purification, handling lipids or fluorescence microscopy would be an advantage. You should like the idea of working in a diverse, collaborative, ambitious and international environment. Excellent verbal and written English skills are essential. You will need to hold an MSc-degree, to ensure eligibility for a Dutch PhD examination.

IMPORTANT: for this position, you must also meet the EU’s “Mobility conditions”:

- MSCA networks require that applicants must not have studied/worked in the host country for more than 12 months in the 3 years immediately prior to the position’s start date.
- This project’s Host Institution is AMOLF, but a part of your doctoral studies will be spent in the laboratory of a consortium member (likely 6 months, the maximum being 12 months).

**Work environment**:
**Working conditions**:

- IMPORTANT: in line with Dutch regulations, this PhD project has a duration of 48 months, i.e. 12 months on top of the 36 months funded by SigSynCell.

**More information?**:
For further information about the position, please contact dr. Kristina Ganzinger:
dr. Kristina Ganzinger
Group leader Physics of Cellular Interactions
Phone: +31 (0)20-754 7100

**Application**:
You can respond to this vacancy online via the button below.
Please annex your:

- Resume;
- Motivation on why you want to join the group (max. 1 page).

Applications will be evaluated on a rolling basis and as soon as an excellent match is made, the position will be filled.

Online screening may be part of the selection.

**Diversity code**:
AMOLF has won the NNV Diversity Award 2022, which is awarded every two years by the Netherlands Physical Society for demonstrating the most successful implementation of equality, diversity and inclusion (EDI).

**_Commercial activities in response to this ad are not appreciated._

  • Postdoc: Discovering Car T Cell Biophysics with

    6 uur geleden

    Amsterdam Oost, Nederland AMOLF Voltijd

    **Postdoc: Discovering CAR T cell biophysics with single-molecule TIRF microscopy**: **Work Activities**: Notably, a complex spatio-temporal dynamics is thought to be central to CAR T cell activation, but is difficult to measure and hence remains poorly understood. That the activation relies on the movement and association of many receptors and accesory...

  • Postdoc: Discovering Car T Cell Biophysics with

    6 uur geleden

    Amsterdam Oost, Nederland AMOLF Voltijd

    **Work Activities**: Notably, a complex spatio-temporal dynamics is thought to be central to CAR T cell activation, but is difficult to measure and hence remains poorly understood. That the activation relies on the movement and association of many receptors and accesory proteins in an orchestrated manner is a fascinating notion. By addressing this question...

  • Finance Internship

    2 dagen geleden

    Amsterdam, Nederland Jack Link's Protein Snacks Voltijd

    **Company Description** Make a difference in the world of branded protein snacking as Finance Intern at Jack Link’s EMEA. About Our family owned and value driven business is dedicated to crafting protein-packed snacks that are loved by consumers worldwide. Our array of brands include some of the fastest growing and innovating protein snack brands such as...

  • Communications Officer

    3 weken geleden

    Amsterdam Oost, Nederland AMOLF Voltijd

    **Communications Officer**: **Work Activities**: Are you passionate about science communication and skilled at making complex knowledge accessible to a broad audience? Do you thrive in an environment of highly educated professionals and enjoy collaborating with scientists to craft clear, engaging messages? AMOLF and ARCNL are looking for an enthusiastic and...

  • Communications Officer

    3 weken geleden

    Amsterdam Oost, Nederland ARCNL Voltijd

    **Work Activities**: Are you passionate about science communication and skilled at making complex knowledge accessible to a broad audience? Do you thrive in an environment of highly educated professionals and enjoy collaborating with scientists to craft clear, engaging messages? AMOLF and ARCNL are looking for an enthusiastic and pragmatic Communications...

  • Technician Qc Protein Analytics

    4 dagen geleden

    Amsterdam, Nederland Wacker Chemie AG Voltijd

    Do you want to take responsibility and make a difference with your work? With your expertise, we can achieve great goals together. We are WACKER - Reliable. Determined. Ambitious. As one of the world's most research-intensive chemical companies, we've been making countless products that are an integral part of your everyday life possible for over 100 years....

  • Postdoc: Chaperone-guided Formation of Single

    4 dagen geleden

    Amsterdam Oost, Nederland AMOLF Voltijd

    **Work Activities**: Do you want to discover how multi-protein assemblies are produced without error? The aim of this project is to reveal this vital cellular process at the single-molecule level. Our research group has been at the vanguard of studying chaperone-protein interactions using optical tweezers, which allows one to follow the movements and folding...

  • Senior Analytical Technician Protein Analytics

    2 dagen geleden

    Amsterdam, Noord-Holland, Nederland Grafton Recruitment Voltijd € 72.000

    Job OverviewThe role of a Senior Analytical Technician in Protein Analytics at our organization involves participation in analytical projects related to HPLC, UPLC, LC-MS, and bioassays. The successful candidate will ensure GMP compliance while mentoring technicians and troubleshooting complex issues. This position also supports method validation, stability...

  • Laboratory Technician Protein Analytics

    1 week geleden

    Amsterdam, Noord-Holland, Nederland Grafton Recruitment Voltijd

    Position: Sr. Technician Protein Analytics | Biotech QC | GMP | AmsterdamSalary: Up to €72,000 per yearLocation: Amsterdam, The NetherlandsContract: Permanent, Direct HireWork Model: Full-Time (40h), On-siteJoin a world-class Biotech & Pharmaceutical Manufacturing company in Amsterdam as a Senior Technician in Protein AnalyticsWhat You'll DoAs a Sr....

  • Laboratory Technician Protein Analytics

    1 week geleden

    Amsterdam, Noord-Holland, Nederland Grafton Recruitment Voltijd

    Position: Sr. Technician Protein Analytics | Biotech QC | GMP | Amsterdam Salary: Up to €72,000 per year Location: Amsterdam, The Netherlands Contract: Permanent, Direct Hire Work Model: Full-Time (40h), On-site Join a world-class Biotech & Pharmaceutical Manufacturing company in Amsterdam as a Senior Technician in Protein Analytics What You'll Do As a Sr....

  • Laboratory Technician Protein Analytics

    1 week geleden

    Amsterdam Metropolitan Area, Nederland Grafton Recruitment Voltijd

    Position: Sr. Technician Protein Analytics | Biotech QC | GMP | AmsterdamSalary: Up to €72,000 per yearLocation: Amsterdam, The NetherlandsContract: Permanent, Direct HireWork Model: Full-Time (40h), On-siteJoin a world-class Biotech & Pharmaceutical Manufacturing company in Amsterdam as a Senior Technician in Protein AnalyticsWhat You'll DoAs a Sr....

  • Laboratory Technician Protein Analytics

    4 weken geleden

    Amsterdam, Nederland Grafton Recruitment Voltijd € 72.000

    Position: Sr. Technician Protein Analytics | Biotech QC | GMP | Amsterdam Salary: Up to €72,000 per year Location: Amsterdam, The Netherlands Contract: Permanent, Direct Hire Work Model: Full-Time (40h), On-site Join a world-class Biotech & Pharmaceutical Manufacturing company in Amsterdam as a Senior Technician in Protein Analytics! What...

  • Innovation Strategist for Branded Snacks

    2 dagen geleden

    Amsterdam, Noord-Holland, Nederland Nigel Wright Group Voltijd

    We are seeking an experienced innovation strategist for branded snacks to join our team in Amsterdam. This role is a great opportunity for a motivated and ambitious professional to contribute to the company's success by co-creating and rolling out innovations for the 4 brands (BiFi, Peperami, Jack Link's and Minuets) in the international office.About UsJack...

  • Senior Protein Analyst

    2 dagen geleden

    Amsterdam, Noord-Holland, Nederland Grafton Recruitment Voltijd € 72.000

    Company OverviewGrafton Recruitment is a leading recruitment agency specializing in Biotech and Pharmaceutical Manufacturing.Job DescriptionWe are seeking an experienced Senior Technician to join our client's world-class Biotech & Pharmaceutical Manufacturing company in Amsterdam as a Senior Technician in Protein Analytics.The successful candidate will...

  • Talent and Learning&development Manager

    3 weken geleden

    Amsterdam, Nederland Jack Link's Protein Snacks Voltijd

    **Company Description** Jack Link’s is the global leader in protein snacks, known for its premium beef jerky and iconic brands like BiFi and Peperami. With roots dating back to the 1880s, this family-owned company combines tradition with innovation to deliver high-quality, flavorful snacks worldwide. The EMEA headquarters, located in the vibrant Houthaven...

  • Laboratory Technician Protein Analytics

    4 weken geleden

    Amsterdam Metropolitan Area, Nederland Grafton Recruitment Voltijd

    Position: Sr. Technician Protein Analytics | Biotech QC | GMP | AmsterdamSalary: Up to €72,000 per yearLocation: Amsterdam, The NetherlandsContract: Permanent, Direct HireWork Model: Full-Time (40h), On-siteJoin a world-class Biotech & Pharmaceutical Manufacturing company in Amsterdam as a Senior Technician in Protein Analytics!What You’ll DoAs a Sr....

  • Laboratory Technician Protein Analytics

    3 weken geleden

    Amsterdam Metropolitan Area, Nederland Grafton Recruitment Voltijd

    Position: Sr. Technician Protein Analytics | Biotech QC | GMP | AmsterdamSalary: Up to €72,000 per yearLocation: Amsterdam, The NetherlandsContract: Permanent, Direct HireWork Model: Full-Time (40h), On-siteJoin a world-class Biotech & Pharmaceutical Manufacturing company in Amsterdam as a Senior Technician in Protein Analytics!What You’ll DoAs a Sr....

  • Head of Communications

    6 uur geleden

    Amsterdam, Nederland Skytree Voltijd

    **WE ARE SKYTREE** Skytree enables a transition to a world with cleaner Air for everyone. We do this by developing and deploying smart technology that captures atmospheric carbon dioxide, enabling its use or storage to combat climate change and aid society and businesses around the world. Born out of the European Space Agency (ESA), we are a global team of...

  • Content & Communication Officer

    3 weken geleden

    Amsterdam, Nederland Adecco Voltijd

    For the European Medicines Agency we are looking for a Communication Officer in Online Communication Service department! What are you going to do? Role summary: ~ As a Communication Officer in EMA's Webteam, you will br respomsible for writing, editing, publishing...]]

  • Communication Officer, Amsterdam

    3 weken geleden

    Amsterdam, Nederland Adecco Voltijd

    For the European Medicines Agency we are looking for a Communication Officer in Online Communication Service department! What are you going to do? Role summary: As a Communication Officer in EMA's Webteam, you will br respomsible for writing, editing, publishing...]]>