PhD Position in Molecular Mechanisms of Bleeding Disorders

4 weken geleden

Rotterdam, Zuid-Holland, Nederland Erasmus MC Voltijd
Job Description

We are seeking a highly motivated and skilled PhD candidate to join our research team at the Erasmus MC. The successful candidate will be part of a collaborative project between the Department of Hematology and the Department of Molecular Immunology, focusing on the molecular mechanisms of bleeding disorders.

Research Project

The project aims to identify the organelle trafficking routes responsible for Weibel-Palade body formation and secretion. This is crucial for understanding the pathophysiology of bleeding disorders such as Von Willebrand disease. The candidate will conduct biochemical assays and optical assays to determine changes in secretory competence and fusion mode due to altered SNARE sorting.

Methodologies

The candidate will utilize a range of advanced microscopy techniques, including Förster resonance energy transfer-fluorescence lifetime imaging (FRET-FLIM), to map SNARE protein trafficking to Weibel-Palade bodies. Other techniques include high content microscopy, proteomics, total internal reflection fluorescence (TIRF) microscopy, shRNA library screenings, and electron microscopy.

Requirements
  • Master's degree in molecular biology, biochemistry, cell biology, biomedical sciences, or a related field.
  • Excellent communication and presentation skills, with fluency in English (oral and written).
  • Self-motivated, detail-oriented, and adept at both independent and collaborative work.
  • Extensive hands-on practical laboratory experience, with previous experience in mammalian cell biology and advanced microscopy approaches an advantage.
  • Willingness to spend research time in Groningen.
Terms of Employment
  • Temporary position for 4 years, with a gross monthly salary of € 3,017,- in the 1st year and increasing to € 3,824,- in the 4th year (scale OIO).
  • Excellent fringe benefits, including a 13th month payment and individual travel expense package.
  • Pension insurance with ABP, with the company contributing approximately 2/3 of the monthly contribution.
  • Special benefits, such as an in-company physiotherapist and bicycle repairer, as well as access to a gym.
How to Apply

Interested candidates should submit their application, including a motivation letter (max 1 page), up-to-date CV (max 2 pages), list of grades for MSc degree, and contact details or letters of recommendation of two references. Screening of applications will start as soon as applications are received and will continue until the position is filled.

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