PhD Position in Molecular Mechanisms of Bleeding Disorders

3 weken geleden


Rotterdam, Zuid-Holland, Nederland Erasmus MC Voltijd
Job Description

Von Willebrand Factor (VWF) plays a crucial role in blood coagulation. Dysfunctional biogenesis and exocytosis of Weibel-Palade bodies (WPBs) are characteristic of bleeding disorders such as Von Willebrand disease. In this project, we aim to identify the organelle trafficking routes responsible for WPB formation and secretion.

Research Objectives
  • To investigate the molecular mechanisms of WPB biogenesis and exocytosis
  • To identify the organelle trafficking routes responsible for WPB formation and secretion
  • To develop novel therapeutic strategies for bleeding disorders
Methodologies

The project will employ a combination of biochemical, cell biological, and microscopy approaches, including high content microscopy, proteomics, total internal reflection fluorescence (TIRF) microscopy, shRNA library screenings, and electron microscopy.

Requirements
  • Master's degree in molecular biology, biochemistry, cell biology, or a related field
  • Excellent communication and presentation skills
  • Self-motivated, detail-oriented, and adept at both independent and collaborative work
  • Extensive hands-on practical laboratory experience
  • Previous experience with mammalian cell biology and advanced microscopy approaches is an advantage
Terms of Employment
  • Temporary position for 4 years
  • Gross monthly salary € 3,017,- in the 1st year and increases to € 3,824,- in the 4th year
  • Excellent fringe benefits, including a 13th month and individual travel expense package
  • Pension insurance with ABP
More Information

A PhD training program is part of the agreement, and the successful candidate will be enrolled in the Erasmus MC Graduate School. For more information, please contact Dr. ir. Ruben Bierings or.



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