PhD Researcher in Transcription Factor Binding

4 weken geleden


Leiden, Zuid-Holland, Nederland Universiteit Leiden Voltijd
Research Opportunities at Universiteit Leiden

We are seeking two PhD candidates to join our research team at the Leiden Institute of Physics and the Netherlands Cancer Institute. Our research focuses on understanding the mechanisms of transcription factor binding at the single-molecule level.

Project Overview

Our research aims to uncover how transcription factor binding dynamics and cooperativity are regulated by nucleosomes, self-interactions, and DNA shape. We will use a combination of single-molecule imaging and in vitro eukaryotic transcription assays to investigate these mechanisms.

Key Responsibilities
  • Design and conduct experiments to study transcription factor binding kinetics
  • Analyze data and draw conclusions about transcription factor cooperativity
  • Collaborate with the research team to develop new assays and techniques
  • Present research findings at conferences and in publications
Requirements

We are looking for ambitious and enthusiastic PhD candidates with a strong background in biophysics, molecular biology, biochemistry, or quantitative biology. Previous experience with single-molecule force spectroscopy and/or fluorescence, protein purifications, or in vitro eukaryotic transcription assays is advantageous.

What We Offer

We offer a dynamic and collaborative research environment, with access to state-of-the-art facilities and equipment. Our team is committed to supporting the development of our PhD candidates and providing opportunities for professional growth.



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