Postdoctoral Research Fellow in Nanomedicine and Drug Delivery

4 weken geleden

Utrecht, Utrecht, Nederland HKU Voltijd
Postdoctoral Fellow in Drug Delivery, Nanomedicine & Advanced Therapeutics

We are seeking a highly motivated and experienced postdoctoral fellow to join our research team at the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine. The successful candidate will have a strong background in drug delivery, nanomedicine, and advanced therapeutics, and will be responsible for designing and developing novel therapeutic approaches for cancer and neurodegenerative diseases.

Key Responsibilities:
  • Design and develop small molecules, nucleic acids, and peptide therapeutics for cancer and neurodegenerative diseases.
  • Design, prepare, and characterize nanoparticles for targeted drug delivery.
  • Employ state-of-the-art techniques to assess the physicochemical properties of nanoparticles, including stability, drug release kinetics, encapsulation efficiency, and electron microscopy imaging.
  • Integrate innovative approaches to enhance the specificity and efficiency of advanced therapeutics, with a particular emphasis on addressing challenges related to tissue penetration and targeted delivery.
  • Conduct cell culture studies using cell lines, primary cultures, and/or patient tissues for efficacy evaluation.
  • Conduct in vivo studies, including administration of nanoparticles, monitoring fate, therapeutic response, and assessing the impact on disease progression.
  • Develop relevant disease models to assess therapeutic efficacy of specific treatments.
  • Demonstrate understanding of disease pathology for better design of advanced therapeutics.
  • Coordinate with clinical collaborators to obtain ethical approvals and obtain human tissue samples for subsequent studies.
  • Engage in collaborative projects both internally and externally.
  • Periodically report progress to PI, co-investigators, project collaborators, and project funder.
  • Initiate and contribute to grant writing activities.
  • Write study-specific procedures for analytical methods, protocols, and reports and provide training on processes and equipment.
  • Supervise and co-supervise undergraduate and postgraduate students.
  • Disseminate research findings through the preparation of research articles and presentations at international conferences.
  • Foster an agile and friendly working environment within the research group.
Requirements:
  • Ph.D. in Pharmaceutical Sciences, Pharmacology, Biology, Molecular Biology, Biochemistry, Immunology, Bioengineering, Chemistry, Data Science, or related fields.
  • Postdoctoral experience preferred.
  • Proven track record in conducting high-quality biological or chemical research.
  • Demonstrated history of writing reports and scientific articles based on research results.
Desirable Skills:
  • Strong background in various research areas, including pre-clinical studies, image-guided delivery, nucleic acid therapeutics, targeting and therapeutic aptamers/peptides, immunotherapy, RNA biology, nose-to-brain delivery, blood brain barrier targeting, nanoparticle formulation, peptide therapeutics, T cells therapy, extracellular vesicles, cancer vaccines, brain cancer, motor neuron disease, protein corona, hydrogels, and gene therapy/editing.
  • Hands-on experience in advanced cell culture techniques and in vivo models.
  • Proficiency in various cell and molecular biology experimentation techniques, including PCR, gels, Western blotting, Immunohistochemistry, ELISA, and flow cytometry, immune profiling.
  • Experience in bioconjugations.
Administrative and Collaborative Skills:
  • Ability to manage a research programme financially and administratively under the guidance of the Principal Investigator.
  • Ability to work independently with excellent problem-solving skills, collaborate within a team, and supervise students.
  • High attention to detail in experimental design and execution with a willingness to adapt to new procedures and undergo further training as necessary.
Language and Technical Competence:
  • Excellent command of written and spoken English.
  • Capable of writing grants and contributing to additional funding acquisition.
  • Proficient in IT skills for efficient data management and communication within the research programme.
What We Offer:

The appointment will commence as soon as possible on a temporary basis for 1 year, with the possibility of renewal up to 3 years subjected to satisfactory performance and funding availability. A highly competitive salary commensurate with qualifications and experience will be offered. Other benefits include annual leave, medical benefits, and free access to on-campus gyms and libraries.

The University is an equal opportunities employer and is committed to equality, ethics, inclusivity, diversity, and transparency.

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