Mitigating Neurological Decline in Leukodystrophy Research

7 dagen geleden


Amsterdam, Noord-Holland, Nederland Amsterdam UMC Voltijd
About the Project

Our research team at Amsterdam UMC is dedicated to improving our understanding of leukodystrophies and developing effective treatments. One area of focus has been vanishing white matter (VWM), a condition that primarily affects children. We have made significant strides in identifying the underlying genes and characterizing the disease's progression.

The disease is marked by chronic neurological decline, with patients experiencing worsening symptoms, becoming wheelchair-bound, and eventually passing away. Brain MRIs reveal progressive white matter abnormalities that do not improve. Acute episodes of neurological decline can be triggered by physical stresses such as fever or infections, leading to rapid deterioration in some cases.

Recent advances have led to promising therapeutic interventions aimed at addressing the mechanisms driving chronic neurological decline. Our project seeks to explore ways to mitigate acute episodic neurological decline, including investigating its underlying mechanisms and testing potential treatments.

About the Role

You will work on several key tasks:



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