MD PhD Position in Cancer Immunotherapy

6 dagen geleden

Amsterdam, Noord-Holland, Nederland Netherlands Cancer Institute Voltijd
Job Title: MD PhD Position in Cancer Immunotherapy

We are seeking a highly motivated and talented physician to join our research team at the Netherlands Cancer Institute (NKI). The successful candidate will work on a project focused on personalized neoadjuvant cancer immunotherapies.

Job Description:

Project Overview

The NKI has pioneered neoadjuvant (pre-operative) application of immunotherapy, which is currently the most promising therapy in early-stage cancers. Our group was the first to show that neoadjuvant immune checkpoint inhibition is superior to adjuvant therapy in expanding tumor resident T cells in stage III melanoma patients. We are now running a large phase 3 trial testing neoadjuvant versus adjuvant checkpoint inhibition in stage III melanoma.

Research Focus

The successful candidate will work on identifying baseline signatures for response and toxicity prediction to allow an optimal risk-balance therapy of the individual patient. This will involve analyzing baseline tumor biopsies, serum cytokine levels, the patients' auto-antibody repertoire, and digital datasets of patient-reported outcome measurements.

Requirements

  • A degree in medicine.
  • A keen interest in high-throughput data analysis, for example DNA and RNA sequencing and single cell sequencing.
  • Basic skills in bioinformatics programming languages (e.g. R or Python).
  • Good cross-disciplinary collaborative and communication skills.
  • Experience in statistics, machine learning, and experience with projects involving genomics to identifying candidate targets and biomarkers would be a plus.
  • Good understanding in cancer biology and immunology.

What We Offer

You will join an international research group and collaborate with cancer immunologists, oncologists, and be embedded in a bioinformatics group. You will work with datasets that are unique in the world and at the forefront of cancer immunotherapy. Your work will have immediate impact on patient treatment and investigator-initiated study designs.

This is a temporary employment contract for a period of at least 4 years. Depending on experience, the salary amounts to a minimum of € 3195,- to a maximum of € 3879,- according to the standard PhD scales with a full-time employment of 36 hours per week.

During your PhD, you have the opportunity to participate in courses offered by the Research School Oncology Amsterdam (OOA). In addition to these employment conditions, the NKI-AVL offers an excellent working atmosphere in a specialized hospital. We can also help you find accommodation in the region.

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