Phd Position in Computational Metabolic Modelling
2 maanden geleden
PhD Position in Computational Metabolic Modelling of the Infant Gut and Oral Microbiome
**Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:01.06.2024**Vacaturenummer**:12952- Gut and oral microbiota develop rapidly during early life and are essential for our health during infancy and later in life. Many factors potentially impact this development, including delivery modes, neonatal feeding (breast or formula), exposure to antibiotics, and maternal and infant diet. Changes in the microbiota by these factors can, in turn, substantially impact the immune system, hence the infant’s susceptibility to the development of chronic diseases. However, the mechanisms that relate these factors to our gut and oral microbiota are still unclear.- Understanding this complex interaction will pave the way to the discovery of new targets for interventions aimed at improving health. This position is supported by the NWA program METAHEALTH focusing on oral and metabolic health in infants.-
**What are you going to do?**
- You are expected:
- to complete a PhD thesis within the official appointment duration of four years;
- to develop metabolic models of microbiome species and perform simulations in a community setting to study
- the infant gut and oral microbiome and relate external factors, such as feeding behaviour, to changes- in the microbiota and the produced metabolites;- to use published genome scale metabolic models, tune them with genomic information from cohort studies,
- create new models, validate models with in vitro data, and develop methods for effective simulations- of communities;- to closely collaborate with researchers within the METAHEALTH project performing in vitro experiments,
- those analysing cohort data and those using different computational models. The aim is to produce- community models that represent the gut and oral microbiome for prediction of interventions that could- benefit infant health;- to contribute to the teaching effort of the group, including supervision of bachelor and master students;
- to present your results at seminars and (inter)national conferences.
**What do we require?**
- a degree (MSc, or equivalent) in Systems Biology, Computational Biology, Mathematical Biology or-
- fluency in English, both written and spoken;
- interest in studying biology with computational models;
- skilled in computational research, with strong programming skills;
- a strong interest for collaboration with experimental biologists;
- desirable methodological skills: experience with (genome scale) metabolic models;
- knowledge of biochemistry and microbiology and good mathematical skills.**Our offer**
- We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.-
- Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.**Questions?**
Do you have questions about this vacancy? Or do you- dr. Meike Wortel
**About us**
- The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.
- The Swammerdam Institute for Life Sciences is one of the Faculty of Science’s largest institutes. Its approximately 240 scientists and staff members work in 19 research groups that perform excellent research centered on four themes: Neurosciences, Cell & Systems Biology, Microbiology and Green Life Sciences.**Application**- Applications in.pdf should include:
- a motivation letter and CV, including a list of publications,
- contact information of referees.
- Please mention the months (not just years) in your CV when referring to your education and work experience.-
- A knowledge security check can be part of the selection procedure.
- (for details: National knowledge security guidelines)- The UvA is an equal-opportunity employer. We prioritize diversity and are committed to creating an inclusive environment for everyone. We value a spirit of enquiry and perseverance, provide the space to keep asking questions, and promote a culture of curiosity and creativity._
-
Phd Position in Computational Metabolic Modelling
1 week geleden
Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam VoltijdPhD Position in Computational Metabolic Modelling of the Infant Gut and Oral MicrobiomeFaculteit/Dienst:Faculteit der Natuurw, Wiskunde & InformaticaOpleidingsniveau:MasterFunctie type:PromotieplaatsSluitingsdatum: Vacaturenummer:12952- Gut and oral microbiota develop rapidly during early life and are essential for our health during infancy and later in...
-
Amsterdam, Nederland Universiteit van Amsterdam VoltijdWhat are you going to do ? You are expected: • to complete a PhD thesis within the official appointment duration of four years; • to develop metabolic models of microbiome species and perform simulations in a community setting to study the infant gut and oral microbiome and relate external factors, such as feeding behaviour, to changes ...
-
Phd Position in Multiscale Spatiotemporal Modelling
3 weken geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdPhd Position in Multiscale Spatiotemporal Modelling of Microbiome During the First 1000 Days of Life **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:3 juli 2024**Vacaturenummer**:13092- Are you driven by a desire to delve into the convergence of computational...
-
Phd Position in Multiscale Spatiotemporal Modelling
3 weken geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdPhd Position in Multiscale Spatiotemporal Modelling of Microbiome During the First 1000 Days of Life **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:3 juli 2024**Vacaturenummer**:13092- Are you driven by a desire to delve into the convergence of computational...
-
Phd Position in Multiscale Modelling of Endothelial
1 week geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdPhd Position in Multiscale Modelling of Endothelial Cell Monolayers in Health and Disease **Faculteit/Dienst**:Faculteit der Natuurw., Wiskunde & Informatica**Opleidingsniveau**:Master**Functie type**:Promotieplaats**Sluitingsdatum**:10 juni 2024**Vacaturenummer**:12904- Do you have a passion for life sciences, physiology, or medicine and are eager to...
-
Phd Position in Multiscale Spatiotemporal Modelling
7 dagen geleden
Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam VoltijdPhd Position in Multiscale Spatiotemporal Modelling of Microbiome During the First 1000 Days of LifeFaculteit/Dienst:Faculteit der Natuurw, Wiskunde & InformaticaOpleidingsniveau:MasterFunctie type:PromotieplaatsSluitingsdatum:3 juli 2024Vacaturenummer:13092- Are you driven by a desire to delve into the convergence of computational modelling, omics research,...
-
Amsterdam, Nederland Universiteit van Amsterdam VoltijdWhat are you going to do ? Model Development: Collaborate with an interdisciplinary team of researchers to integrate data from cohort studies, metabolomics analyses and in vitro experiments, to develop computational models relying on spatial modelling techniques such as cellular Potts and reaction-diffusion models that capture the interactions between...
-
Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam VoltijdWhat are you going to do ? Model Development: Collaborate with an interdisciplinary team of researchers to integrate data from cohort studies, metabolomics analyses and in vitro experiments, to develop computational models relying on spatial modelling techniques such as cellular Potts and reaction-diffusion models that capture the interactions between...
-
Amsterdam, Nederland Universiteit van Amsterdam VoltijdWhat are you going to do ? Model Development: Collaborate with an interdisciplinary team of researchers to integrate data from cohort studies, metabolomics analyses and in vitro experiments, to develop computational models relying on spatial modelling techniques such as cellular Potts and reaction-diffusion models that capture the interactions between...
-
Amsterdam, Nederland ARCNL VoltijdWork ActivitiesMaterials are ubiquitous parts of our everyday life and as technologies keep pushing boundaries, the search for new functional materials is getting more and more complex. In this PhD project, you will investigate and design 2D materials with applications in energy storage, semiconductors, and nanolithography. Until now, most research studies...
-
Amsterdam, Noord-Holland, Nederland ARCNL VoltijdWork ActivitiesMaterials are ubiquitous parts of our everyday life and as technologies keep pushing boundaries, the search for new functional materials is getting more and more complex. In this PhD project, you will investigate and design 2D materials with applications in energy storage, semiconductors, and nanolithography. Until now, most research studies...
-
Amsterdam, Nederland ARCNL VoltijdWork ActivitiesMaterials are ubiquitous parts of our everyday life and as technologies keep pushing boundaries, the search for new functional materials is getting more and more complex. In this PhD project, you will investigate and design 2D materials with applications in energy storage, semiconductors, and nanolithography. Until now, most research studies...
-
PhD in Computational Chemistry
2 maanden geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdWhat are you going to do ? This project is focusing on several issues for atomistic simulations with acrylate: establishing more realistic conditions, inferring kinetic information (complementary to experiments) and prediction of thermo-mechanical properties. In atomic simulations, the positions of all molecules and atoms are known and essentially...
-
PhD position MetaHealth
3 weken geleden
Amsterdam, Nederland Vrije Universiteit Amsterdam VoltijdPhD Opportunity: Exploring Host-Oral Microbiome Interactions in Early Life Through 3D Organotypic Models Your function This PhD project is supported by the NWA program METAHEALTH, which focuses on oral and metabolic health in the first 1000 days of life. The PhD candidate will collaborate closely with fellow PhD students studying social behaviour,...
-
PhD position MetaHealth
1 maand geleden
Amsterdam, Nederland Vrije Universiteit Amsterdam VoltijdPhD Opportunity: Exploring Host-Oral Microbiome Interactions in Early Life Through 3D Organotypic ModelsYour functionThis PhD project is supported by the NWA program METAHEALTH, which focuses on oral and metabolic health in the first 1000 days of life. The PhD candidate will collaborate closely with fellow PhD students studying social behaviour, mathematical...
-
PhD position MetaHealth
3 weken geleden
Amsterdam, Nederland Vrije Universiteit Amsterdam VoltijdPhD Opportunity: Exploring Host-Oral Microbiome Interactions in Early Life Through 3D Organotypic ModelsYour functionThis PhD project is supported by the NWA program METAHEALTH, which focuses on oral and metabolic health in the first 1000 days of life. The PhD candidate will collaborate closely with fellow PhD students studying social behaviour, mathematical...
-
PhD in Computational Chemistry
2 maanden geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdWhat are you going to do ? You will do research in network modelling based on graph theory and population balances, mathematical tools describing changes of molecules on a coarse-grained level. The Random Graph approach is further developed to further increase the capability to account for topological features determining the change of molecular...
-
PhD in Computational Chemistry
3 weken geleden
Amsterdam, Nederland Universiteit van Amsterdam VoltijdWhat are you going to do ? You will do research in network modelling based on graph theory and population balances, mathematical tools describing changes of molecules on a coarse-grained level. The Random Graph approach is further developed to further increase the capability to account for topological features determining the change of molecular...
-
Amsterdam, Nederland University of Amsterdam VoltijdDo you have a passion for life sciences, physiology, or medicine and are eager to employ computational science methods to study endothelial cells in the microcirculation? The Computational Science Lab (CSL) within in the Informatics Institute is offering a PhD position focusing on multiscale modelling of Endothelial Cell (EC) monolayers in the...
-
Amsterdam, Nederland University of Amsterdam VoltijdDo you have a passion for life sciences, physiology, or medicine and are eager to employ computational science methods to study endothelial cells in the microcirculation? The Computational Science Lab (CSL) within in the Informatics Institute is offering a PhD position focusing on multiscale modelling of Endothelial Cell (EC) monolayers in the...
