Intern, Translational Data Science

6 maanden geleden

Utrecht, Nederland Genmab Voltijd

At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in science, we believe that being proudly unique, determined to be our best, and authentic is essential to fulfilling our purpose.

The role

Project background:
6 months internship project 'Bridging Species: Building a Cynomolgus Monkey and Human scRNA-seq Database for In-Silico Safety Studies in Antibody Research'

Cynomolgus monkeys (_Macaca fascicularis_) serve as a pivotal model in biomedical research due to their physiological similarities to humans, particularly in immunological responses. With the expanding field of antibody therapy for cancer and other diseases, understanding the nuances of gene expression at the single-cell level between humans and cynomolgus monkeys is paramount. This knowledge is particularly crucial for in-silico safety assessments, which are becoming an essential component of non-clinical evaluations. By simulating biological processes computationally, in-silico studies offer a powerful approach to predict potential adverse reactions and ensure the safety of new therapies before they reach clinical trials. This project aims to establish a comprehensive scRNA database to foster comparative analyses.

**Responsibilities**:
- Database Construction: Develop a robust, user-friendly scRNA database for storing, querying, and analyzing comparative analysis between cynomolgus monkeys and humans at a single-cell resolution.-
- Cell Type Annotation Standards: Establish a dual approach for annotating cell types within the cyno scRNA landscape, utilizing both ontology-based standardization and foundation models (e.g., scGPT, SATURN) for a comprehensive, cross-species comparison framework.- Differential Expression Analysis: Investigate differentially expressed (DE) genes relevant to antibody development, focusing on those coding for potential therapeutic targets.

Expected outcome:
This internship is a great opportunity to dive into pioneering research, contributing to a project that will shape the future of translational medicine and non-clinical safety. Interns will be key in developing a database that aids in creating safer, more effective therapeutic interventions through engaging data analysis.

**Requirements**:- Technical Skills: Proficiency in R or Python; familiarity with scRNA-seq data is helpful.- Soft Skills: Creativity in presenting data, good teamwork skills, and a willingness to learn and contribute to a team.

About You
- You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
- You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
- You are a generous collaborator who can work in teams with diverse backgrounds
- You are determined to do and be your best and take pride in enabling the best work of others on the team
- You are not afraid to grapple with the unknown and be innovative
- You have experience working in a fast-growing, dynamic company (or a strong desire to)
- You work hard and are not afraid to have a little fun while you do so

Locations

Genmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you’re in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.

About Genmab

Genmab is an international biotechnology company with a core purpose guiding its unstoppable team to strive towards improving the lives of patients through innovative and differentiated antibody therapeutics. For more than 20 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational research and data sciences, which has resulted in a proprietary pipeline including bispecific T-cell engagers, next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates. To help develop and deliver novel antibody therapies to patients, Genmab has formed 20+ strategic partnerships with biotechnology and pharmaceutical companies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan.

Our commitment to diversity, equity

  • Intern, Translational Data Science

    6 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Translational Data Science Expert

    3 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    At Genmab, we're committed to driving innovation in cancer research through cutting-edge data science and bioinformatics analyses. As a translational data science expert, you'll play a vital role in supporting the transition of our new drug from discovery to clinical trials.The OpportunityOur translational data science team in Utrecht is seeking a talented...

  • Data Science Intern

    4 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    At Genmab, we're committed to building innovative futures together, by developing antibody products and pioneering therapies that change the lives of patients and the future of disease treatment.The RoleThis exciting opportunity with our translational data science team at Genmab's Utrecht office allows you to dive into the world of single-cell sequencing as...

  • Distinguished Translational Data Science Professional

    4 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleWe are seeking a talented and ambitious student intern to join our translational data science team at Genmab's Utrecht office. The selected candidate will support the transition of a new drug from discovery to clinical trials through various data science analyses.Key ResponsibilitiesValidate preliminary findings with additional ccRCC dataset(s)...

  • Intern, Translational Data Science

    6 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Translational Data Science Collaborator

    4 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    At Genmab, we're committed to creating groundbreaking futures together, by developing innovative antibody products and pioneering therapies that change the lives of patients and the future of cancer treatment and serious diseases. Our team is dedicated to making a difference through our work, and we believe that being uniquely authentic, determined to be our...

  • Intern, Translational Data Science

    6 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in...

  • Translational Research Scientist

    4 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    The RoleWe are seeking a highly skilled Senior Research Associate to join our Translational Research team at Genmab. As a key member of our team, you will play a critical role in the preclinical development of novel antibody products.Your Key Responsibilities:Design, execute, and analyze in vitro experiments to study the mechanism of action of our antibody...

  • Research Scientist, Translational Medicine

    4 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleThe Senior Research Associate, Translational Research will be a key member of the TR team, which is embedded in the global Translational & Quantitative Science department. The TR team focuses on preclinical and translational research for novel antibody products in preclinical development and the early stages of clinical development.Key...

  • Scientist, Translational Research

    3 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleThe Senior Research Associate, Translational Research, is a key member of the Translational & Quantitative Science department.This role is responsible for conducting a broad range of in vitro experiments to study the mechanism of action of antibody products in preclinical development and early clinical stages.The successful candidate will...

  • Senior Translational Research Scientist

    2 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleThe Senior Translational Research Scientist is a critical member of the Translational & Quantitative Science (T&QS) department, embedded in a global team that focuses on preclinical and translational research for novel antibody products.As a key contributor to the TR team, you will be responsible for designing and executing in vitro experiments...

  • Senior Research Scientist

    2 weken geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    Genmab is a dynamic biotechnology company dedicated to transforming the lives of patients with cancer through innovative treatments.About the RoleWe are seeking an experienced Senior Research Scientist to join our Translational Research team, embedded within the global Translational & Quantitative Science department. The successful candidate will contribute...

  • (Senior) Research Associate, Translational Research

    6 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    The Role  The Senior Research Associate, Translational Research (TR), is a member of the TR team, which is embedded in the global Translational & Quantitative Science (T&QS) department. The TR team specifically focusses on preclinical and translational research for novel antibody products in preclinical development and the early stages of clinical...

  • Associate Director, Translational Medicine

    6 maanden geleden

    Utrecht, Nederland Genmab Voltijd

    The Role The Associate Director, Translational Medicine (TM) is a member of the TM team, which is embedded in the global Translational Research & Precision Medicine Department. The TM team focuses on preclinical and clinical translational research to advance the clinical development of innovative and differentiated antibody therapeutics for the treatment of...

  • Director, Program Management, Translational Sciences

    1 maand geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    About the RoleWe are seeking an experienced Director, Program Management, Translational Sciences to lead and shape the project management efforts for our Translational and Quantitative Sciences department. This role reports to the VP, Head of Development Program Management.Key ResponsibilitiesOrganize, structure, and connect research activities in the...

  • Data Science Research Associate

    1 week geleden

    Utrecht, Utrecht, Nederland Genmab Voltijd

    Unlock your potential in a dynamic and collaborative environment at Genmab, a pioneering biotechnology company dedicated to revolutionizing cancer treatment and serious diseases.About the OpportunityWe are seeking a highly motivated Data Science Research Associate to join our translational data science team in Utrecht. As part of this exciting opportunity,...

  • Traineeship Data Science

    2 maanden geleden

    Utrecht, Nederland House of Bèta Voltijd

    **-Dutch speaking and writing proficiency is required-** **Burgers en bedrijven hebben een schat aan informatie tot hun beschikking. Die informatie wordt lang niet altijd optimaal benut, en blijft vaak zelfs onaangeraakt onder het oppervlak verborgen. In ons traineeship Data Science leer je die informatieschatten vinden, opgraven en benutten. Als trainee...

  • Traineeship Data Science

    2 weken geleden

    Utrecht, Nederland House of Bèta Voltijd

    **-Dutch speaking and writing proficiency is required-** **Burgers en bedrijven hebben een schat aan informatie tot hun beschikking. Die informatie wordt lang niet altijd optimaal benut, en blijft vaak zelfs onaangeraakt onder het oppervlak verborgen. In ons traineeship Data Science leer je die informatieschatten vinden, opgraven en benutten. **Jij kent de...

  • Traineeship Data Science

    2 maanden geleden

    Utrecht, Nederland House of Bèta Voltijd

    **-Dutch speaking and writing proficiency is required-** **Burgers en bedrijven hebben een schat aan informatie tot hun beschikking. Die informatie wordt lang niet altijd optimaal benut, en blijft vaak zelfs onaangeraakt onder het oppervlak verborgen. In ons traineeship Data Science leer je die informatieschatten vinden, opgraven en benutten. Als trainee...

  • Traineeship Data Science

    3 maanden geleden

    Utrecht, Nederland House of Bèta Voltijd

    **-Dutch speaking and writing proficiency is required-** **Burgers en bedrijven hebben een schat aan informatie tot hun beschikking. Die informatie wordt lang niet altijd optimaal benut, en blijft vaak zelfs onaangeraakt onder het oppervlak verborgen. In ons traineeship Data Science leer je die informatieschatten vinden, opgraven en benutten. Als trainee...