PhD Researcher in Transcription Factor Dynamics

2 maanden geleden

Leiden, Zuid-Holland, Nederland Universiteit Leiden Voltijd
Research Opportunities at Universiteit Leiden

We are seeking two highly motivated PhD candidates to join our research team at the Leiden Institute of Physics and the Netherlands Cancer Institute. Our group is focused on understanding the dynamics of transcription factor binding at the single-molecule level, and we are looking for talented individuals to contribute to this exciting research area.

About the Projects

Our research team is working on two interconnected projects. The first project aims to uncover how transcription factor binding dynamics and cooperativity are regulated by nucleosomes, self-interactions, and DNA shape. The second project involves designing and building custom chromatin fibers to resolve how these are folded into higher-order structures and how chromatin structure affects transcription factor binding.

Key Responsibilities
  • Conduct single-molecule imaging experiments to measure and perturb the DNA binding kinetics of transcription factors ex vivo
  • Develop a novel assay to map the position of nucleosomes along single chromatin fibers
  • Integrate ex vivo results with simultaneous DNA binding and transcription measurements at a single locus in living yeast cells using our novel tracking technology
Requirements

We are looking for ambitious and enthusiastic PhD candidates with a strong background in biophysics, molecular biology, biochemistry, or quantitative biology. Previous experience with single-molecule force spectroscopy and/or fluorescence, protein purifications, or in vitro eukaryotic transcription assays is advantageous. The candidates should be creative, independent, and have a problem-solving attitude. Good communication skills and the ability to work in a multi-disciplinary team are essential.

What We Offer

As a PhD candidate at Universiteit Leiden, you will have the opportunity to work in a dynamic and collaborative research environment. You will be part of a team of experienced researchers and will have access to state-of-the-art facilities and equipment. We offer a competitive salary and benefits package, as well as opportunities for professional development and networking.

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