Advanced thermo-chemotherapeutic treatment for breast cancer treatment

1 maand geleden

Amsterdam, Noord-Holland, Nederland Amsterdam UMC (Universitair Medische Centra) Voltijd

Vacancies Vacancy: PhD Advanced thermo-chemotherapeutic treatment for breast cancer treatment
PhD Advanced thermo-chemotherapeutic treatment for breast cancer treatment

Development, evaluation and application of novel thermo-chemotherapeutic treatment planning to help improving effectiveness of breast cancer treatment

  • Hours: 36 uur per week
  • Location: Locatie AMC
  • Contract type: project
  • Salary: € € 3.824
    The project
    Breast cancer is the most common cancer for women worldwide. Not all patients respond to chemotherapy for the necessary downstaging to permit breast conserving surgery. The objective of the four year multicenter research project "Development of personalized MR-guided thermo-chemotherapy for breast conserving surgery" is to solve this problem by developing treatment technology for applying and monitoring effective novel personalized breast cancer treatments combining MR-guided local thermotherapy with 'smart' nano-chemotherapy.

    This project is supported by a grant of the Netherlands Organization for Scientific Research NWO and performed at four Dutch centers. The work package at Amsterdam UMC aims to assist treatment delivery by creating a novel form of advanced treatment planning to predict the local drug distribution, and the temperature dependent effectiveness and cytotoxicity of these drugs. This is done in a digital model simulating the flow, heat and drug transport in a breast treated with thermo-chemotherapy. During treatments invasive and non-invasive thermometry will be combined with temperature simulations to reconstruct the true temperature distributions, which are combined with knowledge on temperature-dependent drug effectiveness to compute the combined effect of heat and chemotherapy. Goal is to establish strategies resulting in effective tumor eradication without unacceptable local and systemic side effects.

    We are looking for a PhD student for four years with a physics background for designing and applying this digital model. Examples of a comparable form of modelling we developed for chemotherapy delivery during Hyperthermic IntraPeritoneal Chemotherapy are given in this link and this link.

    A team of physicists, biologists and clinicians will advise on the work performed by the student. About your role

    The PhD student has a physics background and will create the novel form of advanced treatment planning to predict the local drug and temperature distribution, and ultimately the temperature dependent effectiveness and cytotoxicity of these drugs. This involves developing a digital breast tumor model for simulating the flow, heat and drug transport in the breast during thermo-chemotherapy.

    Work will involve development, adaptation and application of advanced computer models simulating various aspects of the thermo-chemotherapy breast cancer treatment, which is novel in the field. About you

    We are looking for a highly motivated candidate with a MSc degree in physics or a related background.

    The candidate preferably has practical experience with mathematical and numerical models in computer simulations and advanced programming in C/C++.

    The candidate should have good command of English.

    Excellent analytical and communicative skills and the ability to work within a multidisciplinary research group are essential.

    The research project should result in a PhD thesis. Our offer

  • A flying start to your career in scientific research.
Plenty of room for personal development with a wide range of training & development of academic skills.
Working on large-scale and own research, with motivated colleagues.
A contract for 6 months with the prospect of extension for the duration.
Salary scale: OIO: € 3.017 tot € 3.824 bruto (based on a fulltime workweek), depending on qualifications and experience.
Additional benefits including an 8.3% end-of-year bonus and 8% holiday pay.
Your pension is accrued at BeFrank. A modern, understandable and fair pension.
Excellent accessibility with public transportation and reimbursement of a large portion of your travel expenses. Additionally, we have plenty of parking spaces at the AMC location and a good bicycle scheme.
About your workplace
The candidate will work at the Department of Radiation Oncology of the Amsterdam University Medical centers, location AMC. The candidate will collaborate with biologists, physicists and clinicians at both locations of Amsterdam UMC, as well as with PhD students working on CARES at TU Eindhoven, UMC Utrecht and Erasmus MC Rotterdam.
The Amsterdam UMC and the PI's for this project are widely acknowledged as leading experts in the field of clinical, pre-clinical and technical research on hyperthermia combined with radiotherapy or chemotherapy. Hyperthermia research is thriving at Amsterdam UMC and preclinical research results are readily translated into clinical practice.
Amsterdam UMC has an open culture. This means that we hope that everyone feels welcome in our organization and that we strive to offer equal opportunities to everyone. We therefore cordially invite all interested parties to respond to this vacancy. What to expect
A job in our beautiful capital city.
Working for the favorite employer in healthcare (intermediary
All colleagues have the same goal: contributing to tomorrow's care.
There is room for development, deepening and broadening of your knowledge.
An active staff association that organizes fun activities and arranges discounts on products and services for you.
Amsterdam UMC innovates continuously, which requires a flexible attitude from everyone.
Two large locations, good for your pedometer
You have more than colleagues, not all of whom you will get to know personally.
Let's meet
During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.
For more information on the project please contact Hans Crezee via via
For more information about the application procedure, please contact Chey Edwards, Recruitment advisor, via or via
A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).
Internal candidates will be given priority over external candidates in case of equal suitability.
Acquisition in response to this vacancy is not appreciated.

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