PhD Researcher: Unraveling the Dynamics of Ubiquitin-Processing Enzymes
3 dagen geleden
The Research Position at AMOLF is available for an outstanding experimental physicist or chemist to contribute to a cutting-edge project in single-molecule biophysics.
Project OverviewThis project aims to elucidate the dynamic mechanisms underlying the function of ubiquitin-processing enzymes, specifically Cdc48/p97. The researcher will employ optical tweezers and single-molecule fluorescence techniques to visualize the binding, unfolding, and translocation of ubiquitin molecules through the central pore of these enzymes.
The study will focus on understanding how these enzymes select target proteins marked with specific polyubiquitin chains, which can exhibit diverse linkages, topologies, and biochemical modifications. This research has far-reaching implications for our understanding of protein degradation, membrane remodeling, and DNA replication regulation.
In this role, you will work closely with the Tans group at AMOLF, which has been at the forefront of studying chaperone-guided protein folding using optical tweezers. You will have the opportunity to develop new experimental schemes, analyze complex temporal data, formulate new models, and explain your findings in high-level scientific papers.
Job RequirementsWe are looking for a highly motivated and talented individual with a strong background in experimental physics or chemistry. The ideal candidate should have experience with single-molecule techniques, programming skills to handle complex data, and excellent verbal and written English skills.
A Master's degree is required to ensure eligibility for a Dutch PhD examination. We offer a stimulating work environment, access to state-of-the-art facilities, and opportunities for professional growth and development.
Working Conditions- The position is full-time (40 hours/week) for four years.
- The salary is €27,811 gross per month, plus benefits.
- After successful completion of the PhD research, a PhD degree will be granted at Delft University of Technology.
- Funding is available to attend international conferences.
- AMOLF assists with housing, visa applications, and transport costs.
AMOLF is a leading research institute that performs fundamental research on the physics of complex forms of matter. We collaborate with academia and industry to create new functional materials and push the boundaries of scientific knowledge.
Our institute is located at Amsterdam Science Park, offering a unique and inspiring environment for researchers and students alike. We strive to maintain a diverse and inclusive work environment and welcome applications from candidates with different backgrounds and perspectives.
-
Amsterdam, Noord-Holland, Nederland AMOLF VoltijdThe Ubiquitin Processing Motor Cdc48/p97 is a pivotal enzyme in cellular regulation, controlling protein degradation, membrane remodeling, and DNA replication. As a PhD Researcher in our group, you will investigate the dynamic action of this motor using innovative (bio)physics experiments. You will work in the Tans biophysics lab at AMOLF Amsterdam,...
-
Researcher in Single-Molecule Biophysics of Protein Unfolding
2 weken geleden
Amsterdam, Noord-Holland, Nederland AMOLF VoltijdCompany OverviewAMOLF is a research institute at the forefront of studying complex forms of matter. Our team performs leading fundamental research on the physics of these materials, creating new functional materials in partnership with academia and industry.Salary and BenefitsThe estimated salary for this position is approximately €27,810 per year, based...
-
Amsterdam, Noord-Holland, Nederland AMOLF VoltijdThe dynamic ubiquitin processing motor Cdc48/p97 plays a pivotal role in cellular functions such as protein degradation, membrane remodeling, and DNA replication regulation. In this project, you will employ innovative (bio)physics experiments to elucidate the mechanism of Cdc48/p97 using optical tweezers and single-molecule fluorescence techniques.Key...
-
PhD Researcher in Phytoplankton Dynamics
1 maand geleden
Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam VoltijdPhD Researcher in Phytoplankton DynamicsWe are seeking a highly motivated PhD researcher to join our team at the University of Amsterdam. The successful candidate will investigate the dynamics of phytoplankton communities in the North Sea, with a focus on understanding the impacts of environmental change on these ecosystems.Key Responsibilities:Conduct...
-
PhD Researcher in EUV Source Size Characterization
1 maand geleden
Amsterdam, Noord-Holland, Nederland ARCNL VoltijdProject OverviewThis PhD research project focuses on developing novel imaging spectroscopy techniques to diagnose plasma dynamics in laser-produced tin plasmas, which are sources of extreme ultraviolet (EUV) radiation for nanolithography. The goal is to understand and optimize alternative laser-produced plasma sources of EUV light.Research ObjectivesThe...
-
PhD Researcher in Cognitive Neuroscience
3 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdAbout the PhD PositionWe are seeking a highly motivated PhD researcher to contribute to our understanding of the reading brain. The successful candidate will join the Snell Language Lab at the Vrije Universiteit Amsterdam, a leading research group in cognitive neuroscience. Our team is dedicated to advancing knowledge in language processing and its neural...
-
Experimental Physicist
4 weken geleden
Amsterdam, Noord-Holland, Nederland AMOLF VoltijdThe ubiquitin processing motor Cdc48/p97 plays a critical role in cellular processes. As an experimental physicist, you will investigate its dynamic action using innovative optical tweezers and single-molecule fluorescence techniques. This project offers a unique opportunity to elucidate the mechanisms underlying this pivotal function, with potential...
-
Amsterdam, Noord-Holland, Nederland ARCNL VoltijdProject OverviewARCNL is seeking a highly motivated PhD student to contribute to the development and application of advanced imaging spectroscopy techniques for characterizing broadband EUV sources. This project is part of a collaborative effort between ARCNL and the University of Twente to further understand and optimize the performance of EUV light sources...
-
MD PhD Researcher in Chemosensing
1 maand geleden
Amsterdam, Noord-Holland, Nederland Netherlands Cancer Institute VoltijdJob Title: MD PhD Researcher in ChemosensingJob Summary: We are seeking a highly motivated MD PhD researcher to join our team at the Netherlands Cancer Institute. The successful candidate will be involved in a four-year project investigating how the menstrual cycle influences breast cancer sensitivity to chemotherapy.Key Responsibilities:- Conduct research...
-
PhD Researcher in Alpine Landscape Evolution
4 weken geleden
Amsterdam, Noord-Holland, Nederland VU Amsterdam VoltijdAbout the ProjectVU Amsterdam is seeking a highly motivated PhD researcher to contribute to a new research project examining the interactions among erosion, topography, and sediment fluxes over millennial timescales in the Western Southern Alps of New Zealand. The project aims to understand how retreating glaciers shape Earth's surface and predict the impact...
-
Molecular Dynamics Researcher: Elucidating Protein Synthesis
2 weken geleden
Amsterdam, Noord-Holland, Nederland AMOLF VoltijdWe are seeking an exceptional researcher to join our team at AMOLF in Amsterdam. As a Molecular Dynamics Researcher, you will be part of a dynamic and collaborative environment where you will have the opportunity to elucidate the fundamental mechanisms of protein synthesis.Our group focuses on understanding the complex interactions between ribosomes,...
-
Advanced PhD Researcher in EUV Lithography
7 dagen geleden
Amsterdam, Noord-Holland, Nederland ARCNL VoltijdAbout ARCNLThe Advanced Research Center for Nanolithography (ARCNL) is a leading research center focused on the fundamental physics and chemistry involved in current and future key technologies in nanolithography, primarily for the semiconductor industry.We are a public-private partnership between the Dutch Research Council (NWO), the University of Amsterdam...
-
PhD Researcher in Nucleic Acids Biophysics
3 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdWe are seeking a highly motivated PhD researcher to join our team at the Vrije Universiteit Amsterdam. As part of the Marie Skłodowska Curie Doctoral Network, you will have the opportunity to work on a cutting-edge project in nucleic acids biophysics using single-molecule techniques.Project OverviewNucleic acids are central to the storage and transmission...
-
PhD Researcher in Speculative Fiction and Futuristic Imaginaries
3 weken geleden
Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam VoltijdResearch OpportunitiesThe Universiteit van Amsterdam is seeking a highly motivated PhD researcher to join a research project exploring the role of speculative fiction in shaping conceptualizations of the future.As a PhD researcher, you will contribute to the development of a research project that investigates how speculative fiction contributes to the...
-
PhD Researcher in Molecular Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdAbout the PositionWe are seeking a highly motivated PhD researcher to join our team at Vrije Universiteit Amsterdam, in the Department of Molecular and Cellular Neuroscience. The selected candidate will work on a project investigating how nanoscale molecular processes at synapses control memory formation.The project involves using CRISPR/Cas9-based tools,...
-
PhD Position in Cognitive Neuroscience
4 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdAbout the PhD PositionWe are seeking a talented and motivated PhD candidate to contribute to our research on the reading brain at the Vrije Universiteit Amsterdam.Job DescriptionThe successful candidate will be part of the Cognitive Psychology group, where our team of researchers focuses on understanding the complex processes involved in language processing....
-
PhD Researcher in Bioinformatics of the Human Microbiome
3 weken geleden
Amsterdam, Noord-Holland, Nederland Universiteit van Amsterdam VoltijdResearch OpportunitiesWe are seeking a talented researcher to join our Biosystems Data Analysis group at the Universiteit van Amsterdam. As a PhD researcher, you will be responsible for designing, applying, and benchmarking bioinformatics algorithms to predict host-microbiome interactions.ResponsibilitiesConduct research in bioinformatics and data science to...
-
PhD Researcher in Biophysical Characterization of Nucleic Acids
2 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdCompany OverviewVrije Universiteit Amsterdam is a research-driven university with a strong focus on education and innovation. As a leading institution in the Netherlands, we strive to create a better world for people and planet through our cutting-edge research and teaching.Job DescriptionWe are seeking a highly motivated PhD researcher to join our team at...
-
PhD Researcher in Single Molecule Biophysics
2 weken geleden
Amsterdam, Noord-Holland, Nederland Vrije Universiteit Amsterdam VoltijdWe are seeking a highly motivated PhD researcher to join our team at the Vrije Universiteit Amsterdam.Job DescriptionThis PhD position is part of the EU-funded Marie Skłodowska Curie Doctoral Network (DN) "MeChaNiSM", which brings together 8 partners and supports up to 15 PhD students in the field of nucleic acids chemistry and biophysics.The successful...
-
PhD Researcher in Droplet-Laser Interaction for EUV Lithography
4 weken geleden
Amsterdam, Noord-Holland, Nederland ARCNL VoltijdJob SummaryWe are seeking a highly motivated PhD researcher to investigate the hydrodynamics of droplet-laser interaction in EUV lithography. The successful candidate will join the EUV Plasma Processes group at ARCNL and contribute to the development of new capabilities for laser-tailoring targets.About the ProjectThe project aims to deliver the missing...